Pathology of G6PD deficiency Pathology Made Simple In G6PD deficiency (XR), we have increased oxidative damage to RBCs, leading to intravascular hemolysis with decreased serum haptoglobin. We have decreased NADPH production, which means decreased conversion of oxidized ( S S ) glutathione Glucose 6 Phosphate Dehydrogenase Deficiency (G6PD) Glucose 6 Phosphate Dehydrogenase an overview ScienceDirect Topics Understanding and Managing Glucose 6 Phosphate Dehydrogenase Deficiency ScienceDirect Diabetes causes inhibition of glucose 6 phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex American Journal of Physiology Renal Physiology American Physiological Society