In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are Oxidative Stress in Healthy and Pathological Red Blood Cells Hemolytic Anemias Part 4: G6PD Deficiency; Pathophysiology,Morphology, clinical features Interplay between Erythrocyte Peroxidases and Membrane IntechOpen L glutamine for sickle cell disease: more than reducing redox Annals of Hematology Springer Nature Link How VitE protects the RBCs membrane. RBCs = red blood cells, VitE = Download Scientific Diagram